Patients with obesity and high blood pressure lack evidence to choose between weight-loss surgery and medicines. This study compares both to help each person pick the option that fits them best.
Why we are doing this study Many people living with obesity also have high blood pressure. Two kinds of treatment can lead to large weight loss and can help lower blood pressure: weight-loss surgery, and a newer group of weight-loss medicines such as semaglutide and tirzepatide (you may know these by brand names like Wegovy, Ozempic, or Zepbound). Both help many people. But we do not yet know which one works better for bringing blood pressure back to a healthy range, or whether the answer depends on how much a person weighs when they start. There is no single right answer for everyone, and the best choice often depends on what matters most to each person. What we want to find out 1. Which treatment is more likely to bring blood pressure back to a healthy range, so a person can stop taking blood pressure pills? And does the answer change depending on a person’s starting weight? 2. How do the two treatments compare on safety, side effects, and how people feel day to day? 3. Do the results differ for different groups of people, for example by age, sex, race or ethnicity, income, type of insurance, or living in a rural or city area? How we will do the study We will not ask anyone to change their care or to try a new treatment. Instead, we will study health information that doctors and hospitals already collect during regular care, from many health systems across the country. We will look at people who started one of these two treatments and follow what happened to their blood pressure, and their blood pressure medicines, over the next year. We will use careful methods to compare similar groups of people as fairly as possible.
How patients help lead this study Patients who have lived with obesity and gone through treatment are part of our team, not just part of the study. They help decide what we measure, how we make sense of the results, and how we share what we learn. Patient partners are paid for their time and have an equal vote in study decisions.
We are seeking partners with a history of obesity, including those who have or have not tried to lose weight with medications or surgery. We are particularly interested in connecting with partners who also receive treatment for high blood pressure; although this is not a requirement. Partners should be between 18 and 75 years old.
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